ABOUT BRIGHTSEED
Brightseed®, the bioactives company is a World Economic Global Innovator that illuminates nature to restore human health. Brightseed’s proprietary AI, Forager®, accelerates bioactive discovery, biological validation, and ingredient formulation from years to months, rapidly revealing new connections between nature and humanity. Brightseed produces clinically proven bioactives for dietary supplements, food & beverage CPG, specialty nutrition and medical foods to power proactive health worldwide. Learn more at brightseedbio.com.
ABOUT BIOACTIVES
Bioactives are compounds found in plants, fungi, and bacteria that also benefit human health. They are an important part of a nutrient dense diet, and their health impact often goes beyond basic nutrition. For example, the bioactive lycopene found in tomatoes has been found to lower the risk of certain types of cancer and heart disease. In addition, there are multitudes of other bioactives that are only accessible through complex interactions within the gut microbiome. One example is the compound salicin found in willow bark, which transforms into salicylic acid when it interacts with gut microbes. Science has long known that bioactives are critical to human health, yet the vast majority remain unknown and are often referred to as the “dark matter” of nutrition.
ABOUT THE ROLE
Brightseed seeks an experienced biological scientist with a background in discovery and characterization of small molecules that address human health. This lab-based role will organize and oversee small molecule screening and characterization projects, driving collaborative research from the bench into preclinical translation. The ideal candidate will lead a team in developing next-generation high-throughput screening strategies, generating evidence to support translation of molecules to clinical outcomes and ultimately, commercialization. If you're passionate about natural molecule research, join our multidisciplinary team of scientists and engineers to advance human health. This role will report to the Director of Discovery, and is based in South San Francisco.
THE IMPACT YOU WILL MAKE
• Develop, source and implement robust high-throughput screening biological assays representing bioactivities of interest, including phenotypic, target-based, biomarker, and other functional assays for hit finding, lead identification, optimization, and mechanistic characterization.
• Design, conduct, and analyze in vitro experiments to characterize the biological activity of natural plant compounds and their potential to address a variety of health conditions.
• Oversee and build upon Brightseed’s molecular biological capabilities and workflows in collaboration with functional teams covering computation, natural products chemistry, metabolomics and translational and clinical research, ensuring the discovery pipeline is populated with high-potential lead compounds.
• Build strong working relationships across cross-functional teams, effectively present scientific data, and ensure seamless program coordination.
• Provide scientific mentorship to the Biology team, support multiple projects with biological science services, and oversee research activities with external collaborators and CROs.
• Meet program/project deliverables on time and within budget, offering practical solutions to problems and contributing to program scoping through Technical Feasibility Documents.
THE EXPERIENCE YOU WILL NEED
• Normally requires a PhD in cell biology, molecular biology, biochemistry, or related biological field; may include post-doctoral experience.
• Senior Scientist - PhD with 6-8+ years related industry experience, or MS with 10+ years related industry experience.
• Individuals who inspire excellence in themselves and those around them.
• Demonstrated success in designing and implementing small molecule screening strategies in early-stage and hit-to-lead discovery programs, with strong experience in cell-based assay development and mechanistic target biology research.
• A comprehensive background in developing, optimizing, and troubleshooting robust functional and binding-based biochemical assays (such as HTRF, luminescence, and fluorescence) is essential.
• Requires experience in working independently in the lab, hands-on experience in operating state-of-the-art analytical systems like MSD, liquid handler, automation system, plate readers and FLIPR.
• Demonstrated leadership in cross-functional collaborations and program management, coupled with the ability to provide analytical and process design skills and root cause analysis within teams.
• Proficient in independently leading research from discovery to early development stages, managing program priorities, and multitasking in rapidly changing environments.
• Capability to integrate, analyze, and interpret extensive scientific datasets to identify lead molecules, alongside a keen attention to detail and a commitment to rigorous data review.
• Self-
Location: South San Francisco, CA
Posted: Aug. 21, 2024, 10:19 a.m.
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