About Us:
We are a startup biotechnology company dedicated to the development of novel cell therapies to cure cancers. The company was founded on pioneering work carried out in the laboratories of Dr. Carl June and Dr. Andy Minn (University of Pennsylvania), Dr. Kole Roybal (UCSF), and Dr. Christopher Garcia (Stanford University). We are using viral vectors, universal targets, and novel cytokine biology to enhance CAR T activity in solid tumors. Our therapeutic approach has potential to be used across multiple tumor types, enabling us to treat significant numbers of cancer patients.
Based in Philadelphia and San Francisco, we are backed with significant investment by prestigious investors including ARCH Ventures and the Parker Institute for Cancer Immunotherapy. At our company, you would become one of our early team members where you would help to define and hone our science, be a vital part of building our culture, and contribute to the company's future success. Here, you would collaborate with a top-notch team who care about patients and each other. We have an ownership mindset and are innovative, curious, driven, and resilient. We take time to build relationships because trust unlocks our ability to debate, share, forgive, and grow together - ultimately in service of our vision to create a universal cure for cancerous solid tumors and improve outcomes for patients.
The Role:
This position will report directly to our Senior Scientist with world-class experience in synthetic biology. As part of a molecular biology and engineering team, this individual will focus on the development of novel construct designs that incorporate designer proteins and other therapeutic candidates into our core CAR-T and viral platforms. In this role you would collaborate cross-functionally and extensively with multiple internal groups.
Key Responsibilities:
• Design, build, and test novel CAR-T and virus construct designs
• Collaborate with high throughput assay teams to expand and validate discovery platform for therapeutic leads
• Execute cell culture assays to assess promising candidate therapeutics and functionally define relevant properties
• Execute research-scale CAR-T and virus manufacturing and testing
• Analyze, document, and report laboratory data in accordance with company SOPs
• Present data, experimental designs and findings clearly and accurately in team meetings and with scientific leadership
Required Experience & Skills:
• Bachelor's degree in Molecular Biology, Bioengineering, Immunology, Cell Biology, Biochemistry, Virology, or related field
• At least 6 months of hands-on experience with standard cloning, mammalian cell culture
• Ability to independently execute and interpret experimental assays related to construct design and utilization
• Collaborative attitude, ability to work in a team and dedicated work ethic
• Strong organizational and planning skills and the desire to work in a flexible and fast-paced, entrepreneurial environment
• Strong verbal and written communication skills
Preferred Experience & Skills:
• One year or more of laboratory experience with standard cloning methods is a plus
• Lentivirus production techniques
• Experience with flow cytometry and analysis with Flowjo software
• Experience with Snapgene or other DNA editor
• Cell sorting experience
• Previous Research Associate level experience
Working Here:
• We offer a highly competitive compensation package with meaningful ownership
• Excellent coverage for medical, vision, dental
• 401(k) with generous match
• Life insurance
• Premium PTO policy
• Additional substantial benefits
We are an equal opportunity employer.
We are committed to inclusion and diversity and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, marital status, national origin, veteran status, disability status or any characteristic protected under applicable law.
Location: San Francisco, CA
Posted: Aug. 20, 2024, 8:58 a.m.
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