What You Will Achieve
The Immunogenicity Sciences Group within the Pharmacokinetics, Dynamics, and Metabolism (PDM) Department of Pfizer's Discovery and Early Development division is an industry-leading team whose mission is to identify key risks associated with unwanted clinical immunogenicity and influence drug design to mitigate those risks.
We are currently seeking an experienced immunogenicity scientist to join this highly innovative team and collaborate with key stakeholders across Pfizer's Research and Development, including Protein Engineering, Clinical Pharmacology, Drug Safety and Pharmaceutical Sciences. The Principal Scientist role will report to the Immunogenicity Sciences Lead and its core functions are the management of a team of lab-based scientists in their pivotal role in drug design and, drive the establishment of novel approaches to support immunogenicity risk assessment and mitigation strategies of Pfizer's diverse biologics portfolio.
This unique opportunity will immerse the successful candidate in a diverse array of biotherapeutics modalities being designed and developed to meet the needs of patients across Oncology, Inflammation and Immunology, Internal Medicine and Anti-infective disease areas. The successful candidate will drive advancement of our immunogenicity risk mitigation capabilities through scientific leadership, and application of fundamental immunology sciences to further improve the efficacy and safety of our biologics.
How You Will Achieve It
• Design ad-hoc immunogenicity risk identification and mitigation strategies for Pfizer's biologic portfolio across all disease areas and modalities, oversee execution, data interpretation and delivery to stake holders
• Closely collaborate with Pfizer's BioMedicine Design protein engineers and Research Units Team to enable the development of robust immunogenicity mitigation strategies in keeping with project objectives and timelines
• Lead a team of scientists to execute de-risking strategies by applying in silico and in vitro tools to deliver high quality actionable data, navigate change of priorities, program accelerations and implementation of innovation
• Identify talent development opportunities to support growth and career progression of team members
• Safeguard diversity, equity and inclusion
• Actively pursue innovation to improve assay suitability, quality, efficiency, and cost effectiveness
• Identify gaps and investigate novel approaches or technologies to advance, improve or optimize scientific practices and procedures in immunogenicity risk assessment and mitigation
• Represent the Immunogenicity Sciences group at Projects Teams meetings from discovery through early clinical development
• Guide and support project Teams in the writing of Integrated Summary of Immunogenicity and other immunogenicity reports
• Contributes to a change-agile, high performing culture of innovation, impact, trust, accountability, and mutual respect in a fast-paced matrix environment
• Demonstrate our values and behaviors of Excellence, Courage, Equity and Joy.
• Exemplify achievements through publications and external communications
Qualifications
Must-Have
• PhD with +4 years of industry experience in drug discovery and development
• MS with 9+ years of industry experience in drug discovery and development
• Recognized expertise in immunogenicity risk assessment of biologics
• Track record of scientific achievement in the field of immunology and immunogenicity
• Understanding of perturbations of the immune system in diseases as diverse as cancer and auto-inflammation
• Demonstrated success in team management, in particular lab-based scientists
• Extensive practical experience of project liaison achieving results in a complex matrix environment
• Proven track record in project management
• Outstanding interpersonal and communication skills
• Track record in publishing own work and through collaborations
Technical Skill Requirements
• Core expertise & formal education in applied Immunology; displays significant knowledge of the fundamental relationships between innate and adaptive immunity with relevant diseases such as autoimmunity and oncology
• Extensive understanding of clinical implications associated with unwanted immune cellular and humoral responses
• Broad experience with state-of-the-art immunogenicity risk assessment tools and analytical platforms, with direct experience in assay design, execution, analysis, interpretation, and application to drug design
• Solid familiarity with format, pharmacology, and immunogenicity of biologics
• Significant knowledge of immunogenicity monitoring and mitigation
• Collaborative skills and effective influencing/partnering skills in a complex, multi-discipline organization
• Understanding of opportunities and challenges related to translation of in vitro and in silico models
• Lead author or a co-author on internal/external publications and posters
• Direct experience in interacting with e
Location: Andover, MA
Posted: Sept. 13, 2024, 9:18 a.m.
Apply Now Company Website